表面改性纯镁的细胞毒性和溶血率

Biocompatibility of Magnesium after Surface Modification by Heat-Organic Films-Treatment

摘要:

介绍了处理前后纯镁细胞毒性和溶血率试验的结果。试验结果表明,小鼠骨髓细胞与纯镁试样直接接触的细胞毒性实验中,纯镁没有对小鼠骨髓细胞的增殖产生明显的毒副作用;但未处理的纯镁试样出现了严重的溶血现象。经过热-有机表面改性后,纯镁试样的溶血率在生物材料允许的<5%的范围之内。本阶段试验提示,经表面改性后的纯镁可望用作生物材料。

Abstract:

Magnesium has almost the same density, elastic modulus and strength as human bone. In fact human body contains much more magnesium than titanium. The challenge of magnesium is to improve its corrosion and biocompatibility to body fluids while it is used as implants. This paper reports the results of a study in which untreated or treated magnesium samples were subjected to cyto-compatibility tests and hemolysis tests. The results show that no the change of cells morphological or inhibitory effect on cell growth were detected in the cyto-compatibility tests. In hemolysis tests, the untreated magnesium had hemolytic effect, whereas the hemolysis of heat-treated and heatorganic filmtreated samples is within the demand (<5%). Therefore, it is very possible to use magnesium and its alloys as hard tissue substitutes if their surface is properly modified.