微/纳米结构和接枝多肽的钛表面生物活性

Bioactivity of Titanium Surfaces with Micro/Nanostructure and Grafted Polypeptide

摘要:

评价了经化学和仿生改性后的4种钛试样的矿化性能。4种表面改性层分别为：锐钛矿纳米管（N），微/纳米结构（MN），纳米管表面接枝精氨酸-甘氨酸-天冬氨酸-半胱氨酸（NR），微/纳米结构表面接枝精氨酸-甘氨酸-天冬氨酸-半胱氨酸（MNR）。结果显示，表面矿化沉积物是羟基磷灰石，同样条件下，试样的诱导矿化能力依次是MNR﹥MN﹥NR﹥N。在生物材料表面构建微/纳米结构并接枝多肽是一种有效的表面改性方法。

Abstract:

The mineralization ability of 4 kinds of titanium implants after chemical and bionic modification was evaluated. The 4 kinds of surface modification layers were anatase nanotubes (N), micro/nanostructure (MN), nanotubes with grafted Arg-Gly-Asp-Cys (NR), micro/nanostructure with grafted Arg-Gly-Asp-Cys (MNR). Results show that the surface mineralization deposition is hydroxylapatite. Under the same condition, the inducing mineralization ability of the samples is MNR>MN>NR>N. Combination of developing micro/nanostructure and grafting polypeptide is an effective way of surface modification for biomaterials.