医用316L不锈钢支架表面磁性膜对血管内皮化的影响

The Effect of Superficial Magnetic Films of 316L Medical Steel Stents on Endothelialization

摘要:

研究了表面磁性膜医用316L不锈钢支架对血管内皮化的影响。通过体外内皮细胞培养和支架粘附内皮细胞的实验来观察体外支架内皮化的情况；并通过动物体内支架植入实验观察评价血管内皮覆盖及血小板粘附及激活情况。结果表明：表面磁性膜支架在体外可以促进内皮细胞的粘附、增殖，支架植入后在体内可以促进血管内皮再生，加速支架内皮化，同时抑制血小板粘附及激活

Abstract:

The effect of superficial magnetic film on vascular endothelialization for the 316L medical stainless steel stent was investigated in this study. The in vitro endothelial response of human umbilical vein endothelium cell (HUVECs) was investigated on the superficial magnetic film 316L medical stainless steel stent vs bare-metal stent surface；as well as the re-endothelialization and platelet adhesion reaction of superficial magnetic film 316L medical stainless steel stent vs bare-metal stent were evaluated with SEM after animal models implantation for 1 month and 3 months. The consequence indicates that the superficial magnetic film 316L medical stainless steel stent can increase the adhesion and proliferation of HUVECs in vitro，and promote the regenesis of vas endothelialization after implantation in vivo, as well as speed the stent endothelialization and inhibite the platelet adhesion reaction and activation, simultaneously