纯镁在动物体内骨诱导性能的研究

Research on Bone Inducement of Magnesium in Vivo

摘要:

将改性前后的4N-Mg以及TC4合金对照样植入白兔股骨，术后2, 6, 12 w时任取1只处死，进行X线片检查，血镁浓度测试，并对标本进行SEM观察、EDS分析，以及组织切片光镜观察。结果表明，骨内植入试验中，动物血镁浓度均在正常值范围之内；镁基植入材料显示出较好的骨结合性和骨诱导性，新生骨组织矿化明显，新生骨层上有排列整齐的破骨细胞；改性镁基材料的腐蚀降解速率明显减小。初步表明镁基材料有较好的骨诱导性能，改性对镁基材料腐蚀降解有调控作用

Abstract:

The 4N-Mg alloys with and without modification and the TC4 alloy were embedded in the thigh bones of rabbits. The slices were tested by X-ray method and the concentrations of Mg2+ ion in blood were measured for the died rabbits after operation for 2, 6, and 12 w, respectively. The specimens were analyzed by SEM and EDS, and tissue slices were observed by optical microscope. The vivo results show that the magnesium concentrations in the blood of two groups of animal subjects were in the normal scale. The Mg-based materials have good bone inducement and show the better capability of bonding with bone. The new bone mineralizes obviously on the interface. And on the new bone, the osteoclast cells array orderly. The untreated magnesium-based materials are corroded faster than the treated magnesium-based materials. All results indicate that the Mg-based materials show better biocompatibility and capacity to induce new bone, and the surface modification has an effect to control the corrosion rate of Mg-based biomaterials