近β生物钛合金表面TiO2纳米管结构膜制备及其对成骨细胞生长的影响

Fabrication of TiO2 Nanotube Array Film on Near-β Titanium Alloy and Its Effects on Osteoblast Growth

摘要:

通过恒电位阳极氧化新型近β钛合金Ti-5Zr-3Sn-5Mo-25Nb（TLM）制备具有不规则取向的TiO2纳米管阵列膜。TiO2膜在SBF中可诱导磷灰石的沉积并形成HA，表明对成骨细胞早期附着无抑制作用，具有良好的细胞相容性。比较可见，在模拟体液浸泡3 d后，具有不规则取向的TiO2纳米管阵列膜的TLM上成骨细胞附着率明显高于具有TiO2纳米管阵列的Ti片，并形成良好的细胞形态。说明阳极氧化进一步改善了TLM钛合金的生物相容性和生物活性，为植入体的早期愈合提供了条件。

Abstract:

Disordered-orientation TiO2 nanotube array films were prepared by constant-potential anodization of a novel near-β titanium alloy Ti-5Zr-3Sn-5Mo-25Nb (TLM). The TiO2 film can induce the deposition of the apatite to form HA in simulated body fluid (SBF), indicating that the film does not restrict early adhesion of the osteoblast and possesses good biocompatibility. By comparison, it is found that the adhesion ratio of osteoblast on TLM with disordered-orientation TiO2 nanotube array films after soaking in SBF for 3 d is obviously higher than that of Ti sheet with TiO2 nanotube arrays, and the cellular morphology is excellent. It is concluded that the anodization can further improve the biocompatibility and bioactivity of TLM titanium alloy.