心血管支架用Mg-Nd-Zn-Zr生物可降解镁合金的性能研究

Performances of Biodegradable Mg-Nd-Zn-Zr Magnesium Alloy for Cardiovascular Stent

摘要:

以Mg-3.13Nd-0.16Zn-0.41Zr（质量分数，%, JDBM）镁合金为研究对象，研究挤压态JDBM的细胞毒性和腐蚀性能。通过热挤压工艺制备出心血管支架用镁合金微管，并观察其组织。采用激光切割、电化学抛光等工艺制备出心血管支架，测试支架表面粗糙度和径向支撑力。结果表明，JDBM镁合金对内皮细胞无毒性，具有理想的耐蚀性能和腐蚀方式；制备出的心血管支架的径向支撑力超过正常成年人血管收缩压的4倍，满足心血管支架对力学性能的要求。

Abstract:

Mg-3.13Nd-0.16Zn-0.41Zr (wt%, JDBM) alloy was chosen and the cell toxicity and corrosion property of the as-extruded JDBM were studied. Magnesium tube was prepared by hot extrusion processing and the microstructure of the tube was observed. The cardiovascular stent was prepared by laser cutting and electrochemical polishing processes. The surface roughness and radial expansion force were tested. The results show that JDBM magnesium alloy exhibits no cell toxicity of Endothelial cell, good corrosion resistance and corrosion mode. The radial expansion force of the prepared cardiovascular stents is over 4 times than that of the maximal vascular compression pressure of normal adult, which meets the requirement of the mechanical properties for cardiovascular stents.