响应曲面法优化制备乙醇胺铂(Ⅳ)

The research of optimization on preparation of ethanolamine hydroxyl platinum(Ⅳ) by response surface ethodology

摘要:

摘 要:为了对制备乙醇胺铂(Ⅳ)的工艺进行优化，在铂浓度、氧化剂用量、氢氧化钠用量单因素设计和实验结果的基础上，采用响应曲面法优化合成条件，建立预测乙醇胺铂(Ⅳ)产率的数学模型。结果表明，影响因子显著性顺序为：铂浓度>NaOH用量>氧化剂用量。当铂浓度为100g.L-1，NaOH用量为2.25倍，氧化剂用量为10%时，预测乙醇胺铂(Ⅳ)的产率为89.26%。实验证明，该模型对乙醇胺铂(Ⅳ)制备条件的优化及产率的预测较为准确可靠。通过样品表征，验证了该化合物的结构式为(NH3CH2CH2OH)2Pt(OH)6。

Abstract:

Abstract： The some parameters of preparation ethanolamine hydroxyl platinum(Ⅳ), such as concentration of platinum, the amount of oxidant and sodium hydroxide, was tested by means of single factors experiment design, and optimized by response surface method. and then established an empirical mathematical model for to predict yield of ethanolamine hydroxyl platinum(Ⅳ). The results demonstrated that the significance of influence factor as followed the order, platinum concentration＞oxidant amount＞NaOH amount. The yield(89.625%)of ethanolamine hydroxyl platinum(Ⅳ) could be obtained under the optimized conditions, platinum concentration 100g.L-1, oxidant amount 10%, and NaOH amount 2.25 times(in mass). The results show that the empirical mathematical model was feasible for the optimized parameters to prepare ethanolamine hydroxyl platinum(Ⅳ) and also to predict its yield. The structural formula of the compounds was verified of (NH3CH2CH2OH)2Pt(OH)6 by the sample characterization.