多孔钛骨组织工程支架设计及孔结构表征

Design and Charaterization of Porous Titanium Scaffold for Bone Tissue Engineering

摘要:

针对目前骨组织工程支架微孔结构难以准确设计制备，提出了一种基于点云的参数化建模 3D打印新方法。通过提取Cube（C）、Diamond(D)、Gyriod(G)三种结构的型面函数点云数据，完成对不同孔结构特征的参数化建模。通过对模型有限元力学分析，对不同孔结构特征的多孔钛骨组织支架进行力学设计与订制。借助激光选区熔融（SLM）3D打印技术，完成对不同孔特征的骨组织支架快速成型。对多孔钛组织支架进行了相关材料学表征，包括孔结构表征与力学性能测试。结果表明：参数化模型的快速成型制造，能够有效地设计制备钛合金骨组织工程支架的孔结构特性，且可有效设计订制支架的机械性能，从仿生的角度实现多孔钛合金骨组织工程支架生物学功能的设计优化。

Abstract:

In order to fabricate bone tissue engineering scaffold accurately, a novel method that combines parametric modeling and 3D printing was proposed. In this method, the scaffold structures were designed using cloud data of molded surface. Firstly, the cloud data containing the surface information of Cube structure, Diamond structure and Gryriod structure were obtained. Then the scaffold structures with different parameters were expressed by mathematical functions. After that, finite element analysis was done to the scaffolds. The mechanical properties of porous scaffolds were calculated based on finite element analysis. Bone tissue engineering scaffolds with differentSporous structures were manufactured by 3D printing. Finally, characterizations of printed titanium scaffolds were done to detect the porosity and mechanical properties. The results show that the parameterized model and rapid prototyping manufacturing can design and fabricate titanium alloy scaffolds with specific pore structure characteristics effectively. And the scaffold"s mechanical properties can be also designed. It realized porous titanium alloy scaffolds with optimized biological functions from the perspective of bionics.