植酸改性对齿科纯钛SLA表面生物活性的影响

Effect of bioactivity on medical titanium SLA surface after modification of phytic acid

摘要:

采用植酸对纯钛SLA表面进行改性处理，然后在模拟体液（SBF）中矿化，研究植酸改性对SLA表面生物活性的影响。通过SEM、EDS和接触角测试等检测方法表征样品的微观形貌、元素组成和润湿性。探讨人骨髓间充质干细胞（hBMSCs）在不同表面的增殖、粘附和分化行为。结果表明：植酸改性SLA表面接触角为0°，为超亲水表面；植酸改性处理提高了SLA表面诱导磷灰石沉积的能力；植酸改性SLA表面可以增加细胞的增殖、粘附和分化，提高SLA表面的生物活性。 关键词：纯钛、植酸、表面改性、生物活性、超亲水性

Abstract:

In this research, the effect of phytic acid on bioactivity of the surface of SLA-titanium was studied, through modification with phytic acid and subsequent mineralization in the simulated body fluid (SBF). The microstructure, chemical properties and wettability was demonstrated, using SEM、EDS and contact angle analysis. Human bone marrow stromal cells (hBMSCs) were cultured on different surfaces to investigate the proliferation, adhesion and differentiation. The results demonstrate that the contact angle of surface modified with phytic acid is 0°, which means it is superhydrophilicity. The ability to induce apatite deposition, as well as the proliferation, adhesion differentiation of cells are improved obviously on SLA-surface, which reflect a better bioactivation treatment as a result of using phytic acid solution.