溶胶-凝胶法制备钛基生物相容性MgO膜

Biocompatible MgO film on titanium substrate prepared by sol-gel method

摘要:

植入物的表面修饰对于获得生物相容性或功能性界面非常重要。本项研究中， 钛金属表面的MgO薄膜在400?C进行溶胶-凝胶化，观察其微观结构、生物活性、抗菌性能和细胞毒性。结果发现，MgO在空气中老化后转化为Mg（OH）2。扫描电镜观察薄膜无裂纹。在模拟体液试验中显示出良好的生物活性，与成骨细胞有良好的相容性，对大肠杆菌有轻微的抗菌作用。MgO薄膜在钛金属生物医学植入物表面改性中具有潜在的应用前景。

Abstract:

Surface modification of implant substrate is very important to obtain a biocompatible or functional interface. In this work, MgO film was sol-gel prepared on titanium substrate by sintering at 400 ?C. Microstructure, bioactivity, cytotoxicity and antibacterial property of the obtained film were investigated. It was found that MgO converted to Mg(OH)2 after ageing in air. The film was crack free observed by scanning electron microscopy. It was bioactive in the simulated body fluid test, biocompatible with osteoblast cells and slightly antibacterial against E. Coli. The MgO film would have potential application in surface modification of biomedical titanium implants.