表面涂层对用于骨组织工程的多孔镁支架的影响

Effect of Surface Coating on Porous Mg Scaffolds for Bone Engineering

摘要:

多孔镁（Mg）支架有利于生物植入，但是由于Mg的高活性，植入后降解速度过快，不利于新骨的形成。为了有效地控制镁支架的降解，研究了3种不同表面涂层对多孔镁支架的影响。通过能量色散光谱仪（EDS），X射线衍射（XRD）和红外傅里叶变换光谱（FTIR）证实支架表面的组成为纯Mg，氧化镁（MgO），磷酸氢钙（DCPD）和硬脂酸（SA）。结果表明，从表面形貌可以看出，SA涂层更光滑，更致密。模拟体液（SBF）的体外降解实验表明，与未涂覆的Mg支架相比，表面涂层可以有效地减慢支架的降解，并且DCPD涂层和SA涂层优于MgO涂层。在第15周时，浸泡在SBF中的DCPD和SA涂层支架的降解率为70％，这可以为新骨的生长提供一定的时间。

Abstract:

Porous magnesium (Mg) scaffolds are beneficial to biological implantation, but because of the high activity of Mg, the degradation rate after implantation is too fast, which is not conducive to the formation of new bone. In order to effectively control the degradation of Mg scaffolds, three different surface coatings, magnesium oxide (MgO), calcium hydrogen phosphate (DCPD) and stearic acid (SA) on the porous Mg scaffolds was prepared and their effects on the scaffolds were investigated. The surface composition of the uncoated scaffold and the coatings was confirmed to be pure Mg, MgO, DCPD and SA by energy dispersive spectrometer (EDS), X-ray diffraction (XRD) and Fourier transforms infrared spectra (FTIR). The results show that SA coating is smoother and more compact in surface morphology. In vitro degradation in simulated body fluid (SBF) indicates that surface coatings can effectively slow down the scaffold degradation, while DCPD coating and SA coating are better than MgO coating in resisting the degradation. The degradation rate of the scaffolds with DCPD and SA coating soaked in SBF is 70% at the 15th week, which provides a certain period of time for the growth of new bone.